Targeted and triggered drug delivery systems
We have a strong interest in improving the therapeutic index of drug delivery systems by enhancing the spatiotemporal precision with which they can be targeted to diseased areas, and/or by controlling when and where they are triggered to release drugs. We have a strong interest in improving the therapeutic index of drug delivery systems by enhancing the spatiotemporal precision with which they can be targeted to diseased areas, and/or by controlling when and where they are triggered to release drugs. We have used pH, oscillating magnetic fields, ultrasound and light as the stimuli for targeting and triggering events. Our light-controlled systems have used UV, visible, and near-infrared light, depending on the application. We have also used upconversion and second harmonic generation to achieve specific effects in vivo. Another goal of these technologies is to making drug delivery controllable by patients in real time (i.e. on-demand drug delivery).
Mechanisms of photoresponsiveness for nanoparticle targeting and drug release.