Kohane Lab

Choi W, Aizik G, Ostertag-Hill C, Kohane DS: A hybrid nanoparticle-protein hydrogel system for prolonged local anesthesia. Biomaterials 2024; read more

Zhu P, Simon I, Kokalari I, Kohane DS*, Rwei AY*: Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system. Advanced Drug Delivery Reviews 2024; read more

Xue T, Li Y, Torre M, Shao R, Han Y, Chen S, Lee D, Kohane DS: Polymeric Prodrugs using Dynamic Covalent Chemistry for Prolonged Local Anesthesia. Ang. Chem. Int. Ed. Engl. 2024; read more

Aizik G, Ostertag-Hill CA, Chakraborty P, Choi W, Pan M, Mankus DV, Lytton-Jean AKR, Kohane DS: Injectable Hydrogel Based on Liposome Self-Assembly for Controlled Release of Small Hydrophilic Molecules. Acta Biomaterialia 2024; read more

Ding T, Wang Y, Meng Y, Wu E, Shao Q, Lin S, Yu Y, Qian J, He Q, Zhang J*, J. Wang*, Kohane DS*, Zhan C*: Reciprocal Interaction with Neutrophils Facilitates Cutaneous Accumulation of Liposomes. ACS Nano 2024; read more

Choi W, Kohane DS: Hybrid Nanoparticle – Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications. ACS Nano 2024; read more

Cullion K, Ostertag-Hill CA, Tang W, Pan M, Kohane DS: Size-dependent nanoparticle accumulation in venous malformations. J  Vasc Anom 2024; read more

Zhang Z, Li X, Yang R, Cullion K, Prugneau L, Kohane DS: Enhancement of trans-tympanic drug delivery by pharmacological induction of inflammation. Mol Pharm 2023; 20: 1375-1381 read more

Tundisi LL, Ataide JA, Fônseca JHL, Silvério LAL, M. Lancellotti A, Paiva-Santos C, D’Ávila MA, Kohane DS, Mazzola PG: Terbinafine nanohybrid: proposing a hydrogel carrying nanoparticles for topical release. Pharmaceutics 2023; 15: 841 read more

Li Y, Owens GE, Kohane DS: Materials for controlled release of local anesthetics. ChemMedChem 2023; 18: e202300009 read more

McGuire A, Ostertag-Hill CA, Aizik G, Li Y, Kohane DS: Benzonatate as a local anesthetic. PLOS ONE 2023; 18: e0284401 read more

Wang D, Li Y, Deng X, Torre M, Zhang Z, Li X, Zhang W, Cullion K, Kohane DS*, Weldon CB*: An aptamer-based depot system for sustained release of small molecule therapeutics. Nat Commun 2023; 14:2444 read more

Hu JHu J, Zhao B, Wen R, Zhang X, Zhang Y, Kohane DS*, Liu Q*: Squaraine dye-sensitized upconversion with enhanced stability and minimized aggregation-caused quenching. Nano Lett 2023; 23: 5209-5216 read more

Zhang Z, Li X, Do C*, Kohane DS*: Enhancement of polymer thermoresponsiveness and drug delivery across biological barriers by addition of small molecules. Heliyon 2023; 9:e16923 read more

Cullion K*, Ostertag-Hill CA*, Pan M, Timko B, Boscolo E, Kohane DS: Ablation of venous malformations by photothermal therapy with intravenous gold nanoshells. Nano Lett 2023; 23: 7092-7099 read more

Li Y, Ji T, Torre M, Shao R, Zheng Y, Wang D, Li X, Liu A, Zhang W, Deng X, Yan R, Kohane DS: Aromatized Liposomes for Sustained Drug Delivery. Nat Commun 2023; 15: 6659 read more

Li Y, Shao R, Ostertag-Hill CA, Torre M, Yan R, Kohane DS: Methyl-branched liposomes as a depot for sustained drug delivery. Nano Lett 2023; 23: 9250-9256 read more

Zhang W, Wang D, Ostertag-Hill CA, Han Y, Li X, Zheng Y, Lu B, Kohane DS: On-demand opioid reversal with an injectable light-triggered polymer-naloxone conjugate. Nano Letters 2023; 23: 10545-10553 read more 

Mehta M, Zhao C, Liu A, Innocent C, Kohane DS: Prolonged retrobulbar local anesthesia of the cornea does not cause keratopathy in mice. Trans Vis Sci Tech 2022; 11: 33

Zhang Y, Wen R, Hu J, Guan D, Qiu X, Zhang Y*, Kohane DS*, Liu Q*: Enhancement of single upconversion nanoparticle imaging by topologically segregated core-shell structure with inward energy migration. Nat Commun 2022; 13: 5927  read more

Chen L, Kuang L, Ross AE, Farhat W, Boychev N, Sharfi S, Kanu LN, Liu L, Kohane DS, Ciolino JB: Topical sustained delivery of miltefosine eluting contact lenses to treat acanthamoeba keratitis. Pharmaceutics 2022; 14: 2750 read more

Zhang Z, Li X, Zhang W, Kohane DS: Drug delivery across barriers to the middle and inner ear. Adv Func Mater 2021; read more

Zhang W, Kohane DS: Keeping nanomedicine on target. Nano Letters 2021; read more

Soeken TA, Ross AE, Kohane DS, Kuang L, Legault GL, Cladwell MC, Brundridge WL, Merkley MB, Ciolino JB, Townley JR: Dexamethasone-eluting contact lens for the prevention of post-photorefractive keratectomy scar in a New Zealand White rabbit model. Cornea 2021; 40: 1175-1180. read more

Tundisi LL, Yang R, Borelli LPB, Alves T, Mehta M, Chaud MV, Mazzola PG, Kohane DS: Enhancement of the mechanical and drug-releasing properties of poloxamer 407 hydrogels with casein. Pharm Res 2021; 38: 515-522. read more

Zhang W, Harty B, Zheng Y, Zhang Z, Li X, Wang D, Kohane DS: Permeation of polyethylene glycols across the tympanic membrane. Giant 2021; 6: 100057. read more

Staffa S, Kohane DS*, Zurakowski D*: Synergy in nanomedicine: what it is not, and what it might be. Nano Letters 2021; 21: 5457-5460. read more

Cullion K, Petishnok LC, Koo H, Harty B, Melero-Martin JM, Kohane DS: Targeting nanoparticles to bioengineered human vascular networks. Nano Letters; 21: 6609-6616. read more

Yu N, Xu Y, Liu T, Zhong H, Xu Z, Ji T, Zou H, Mu J, Chen Z, Liang X-J, Shi L, Kohane DS*, Guo S*: Modular Ketal-Linked Prodrugs and Biomaterials Enabled by Organocatalytic Transisopropenylation of Alcohols. Nat Commun 2021; read more

Ji T, Li Y, Deng X, Rwei AY, Offen A, Hall S, Zhang W, Zhao C, Mehta M, Kohane DS: Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel. Nat Biomed Eng 2021; 5: 1099-1109 read more

Early S, Yang R, X.Li, Zhang Z, van der Valk JC, Ma X, Kohane DS*, Stankovic KM*: Initial method for characterization of tympanic membrane drug permeability in human temporal bones in situ. Front Neurol 2021; 12: 580392. read more

Kuang L, Ross AE, Kanu LN, Romanowski EG, Kowalski RP, Kohane DS, Ciolino JB: A novel, widely-accessible besifloxacin quantification method: application to ocular pharmacokinetic study in rabbits. J Chromatogr B Analyt Technol Biomed Life Sci 2021; 1185: 123010 read more

Shagan, A., Zhang, W., Mehta, M., Levi, S., Kohane, D. S., Mizrahi, B., Hot Glue Gun Releasing Biocompatible Tissue Adhesive. Adv. Funct. Mater. 2020, 30, 1900998. read more

Cullion K, Petishnok L, Santamaria C, Pemberton G, Kohane DS: The effect of acoustic intensity on high-frequency ultrasound-enhanced peripheral nerve blockade. Drug Deliv Transl Res 2020; 10: 1507-1516

Zhang W, Ji T, Li Y, Zheng Y, Mehta M, Zhao C, Liu A, Kohane DS: Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia. Nat Commun 2020; 11:2323. read more

Zhang W, Ji T, Lyon S, Mehta M, Zheng Y, Deng X, Liu A, Shagan A, Mizrahi B*, Kohane DS*: Functionalized Multi-Armed Polycaprolactones as Biocompatible Tissue Adhesives. ACS Applied Materials & Interfaces 2020; 12:17314-17320. read more

Xing Y, Xu Z, Liu T, Shi L*, Kohane D*, Guo S*: Synthesis of poly(acyclic orthoester)s: acid-sensitive biomaterials for enhancing immune responses of protein vaccine. Ang. Chem. Int. Ed. Engl. 2020; 59: 7235-7239. read more

Li Y, Kohane DS: Microparticles, Biomaterials Science 4^th Edition: An Introduction to Materials in Medicine. Edited by Wagner W., Sakiyama-Elbert S.E., Zhang G., Yaszemski M.J. Elsevier, 2020.​

Yu N, Liu T, Zhang X, Gong N, Ji T, Chen J, Liang XJ, Kohane DS, Guo S.  Dually Enzyme- And Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy. Nano Lett 2020; 20: 5465-5472 read more

Bengani LC, Kobashi H, Ross AE, Zhai H, Salvador-Culla B, Tulsan R, Kolovou PE, Mittal SK, Chauhan SK, Kohane DS*, Ciolino JB*: Steroid-eluting contact lenses for corneal and intraocular inflammation. Acta Biomater 2020; 116: 149-161. read more

Dvir T, Timko BP, Kohane DS, Langer R: Nanotechnological strategies for engineering complex tissues, in Nano-enabled medical applications. Edited by Balogh LP. New York, Jenny Stanford Publishing, 2020; read more

Staffa SJ, Kohane DS, Zurakowski D: Quantile Regression and Its Applications: A Primer for Anesthesiologists. Anesth Analg 2019; read more

Wang Y, Liu C-H, Ji T, Mehta M, Wang W, Marino E, Chen J, Kohane DS: Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles. Nat Commun 2019; 10:804 read more

Yang R, Saarinen R, Okonkwo OS, Hao, Y, Mehta, Kohane DS: Trans-tympanic delivery of local anesthetics for pain in acute otitis media. Mol Pharm 2019; read more

Shomorony A, Santamaria CM, Zhao C, Rwei AY, Mehta M, Zurakowski D, Kohane DS: Prolonged duration local anesthesia by combined delivery of capsaicin- and tetrodotoxin-loaded liposomes. Anesth Analg 2019; read more

Zhao C*, Liu A*, Santamaria CM, Shomorony A, Ji T, Wei T, Gordon A, Elofsson H, Mehta M, Yang R, Kohane DS: Polymer-tetrodotoxin conjugates to induce adjustable and prolonged duration local anesthesia with minimal toxicity. Nat Commun 2019; 10: 2566. read more

Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK: Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proc Natl Acad Sci USA 2019; read more

Ross AE*, Bengani LC*, Tulsan R, Maidana DE, Salvador-Culla B, Kobashi H, Kolovou PE, Zhai H, Taghizadeh K, Kuang L, Mehta M, Vavvas D, Kohane DS*, Ciolino JB*: Topical sustained drug delivery to the retina with a drug-eluting contact lens. Biomaterials 2019; read more

Liu Y, Xu Y, Zhang Z, Huo Y, Chen D, Ma W, Sun K, Tonga G, Zhou G, Kohane DS, Tao K: A simple yet multifunctional nanoformulation for eradicating tumors and preventing recurrence with safely low administration dose. Nano Letters 2019; 19: 5515-5523. read more

Woodruff A, Santamaria CM, Mehta M, Pemberton GL, Cullion K, Kohane DS: Prolonged duration topical rorneal anesthesia with the cationic lidocaine derivative QX-314. Trans Vis Sci Tech 2019; 8:28. read more

Ji T, Kohane DS: Nanoscale systems for local drug delivery. Nano Today 2019; 28: 100765. read more

Cullion K*, Petishnok LC*, Ji T, Zurakowski D, Kohane DS: The duration of nerve block from local anesthetic formulations in male and female rats. Pharm Res 2019; 36:179. read more

Liu Y, Huo Y, Yao L, Xu Y, Meng F, Fanqiang L, Li H, Sung K, Zhou G, Kohane DS, Tao K: Transcytosis of nanomedicine for tumor penetration. Nano Letters 2019; 19:8010-8020. read more

Liu Q, Santamaria CM, Wei T, Zhao C, Ji T, Yang T, Shomorony A, Wang BY, Kohane DS: Hollow silica nanoparticles penetrate peripheral nerve and enhance nerve blockade from tetrodotoxin. Nano Letters 2018; 18: 32-37. read more

Cullion K, Rwei AY, Kohane DS: Ultrasound-triggered liposomes for on-demand local anesthesia. Ther Deliv 2018; 9: 5-8. read more

Cullion K, Santamaria CM, Zhan C, Zurakowski D, Sun T, Pemberton GL, McDannold N, Kohane DS: High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade. J Control Release 2018;276:150-156. read more

Wang Y*, Barhoumi A*, Tong R*, Wang W, Ji T, Deng X, Reznor G, Zurakowski D, Kohane DS: BaTiO3-core Au-shell Nanoparticles for Photothermal Therapy and Bimodal Imaging. Acta Biomater 2018;72:287-294. read more

McAlvin JB, Wylie RG, Ramchander K, Nguyen MT, Lok CK, Moroi M, Shmorony A, Vasilyev NV, Armstrong P, Yang J, Lieber AM, Okonkwo OS, Karnik R, Kohane DS: Antibody modified conduits for highly selective cytokine elimination from blood. JCI Insight 2018; 3(13). read more

Cullion K, Kohane DS: Externally-triggered patient-controlled local anesthesia. Pain Management 2018; 8(5):313-315. read more

Yang R, Okonkwo OS, Zurakowski D, Kohane DS: Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane. J Control Release 2018; 289: 94-101. read more

Zhan C, Santamaria CM, Wang W, McAlvin JB, Kohane DS: Long-acting liposomal corneal anesthetics. Biomaterials 2018; 181:372-377. read more

Yang R, Sabharwal V, Shlykova N, Okonkwo OS, Pelton SI, Kohane DS: Treatment of Streptococcus pneumoniae Otitis Media in a Chinchilla Model by Trans-Tympanic Delivery of Antibiotics JCI Insight 2018; 3: e123415. read more

Rwei AY, Wang B, Ji T, Kohane DS: Predicting the tissue depth for remote triggering of drug delivery systems. J Control Release 2018; 286: 555-63. read more

Weldon CB, Ji T, Nguyen M-T, Rwei AY, Wang W, Hao Y, Zhao C, Mehta M, Wang BY, Marini RP, Kohane DS: Nanoscale bupivacaine formulations to enhance the duration and safety of intravenous regional anesthesia. ACS Nano 201813: 18-25. read more 

Schaefers MM, Duan B, Mizrahi B, Lu R, Reznor G, Kohane DS, Priebe GP: PLGA-encapsulation of the Pseudomonas aeruginosa PopB vaccine antigen improves Th17 responses and confers protection against experimental acute pneumonia. Vaccine 2018; (18)31362-8. read more

Agulnik A, Kelly D, Bruccoleri R, Yuskaitis C, Ebrahim-Fakhari D, Sahin M, Burns MM, Kohane DS: Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. Pediatrics 2017; 139: e20161560.  read more

Zhan C, Wang W, Santamaria C, Wang B, Rwei A, Timko BP, Kohane DS: Ultrasensitive phototriggered local anesthesia. Nano Letters 2017;17:660-665. read more

Rwei AY, Zhan C, Wang B, Kohane DS: Multiply repeatable and adjustable on-demand phototriggered local anesthesia. J Control Release 2017 Apr 10;251:68-74.  read more 

Santamaria CM, Woodruff AG, Yang R, Kohane DS: Drug delivery systems for prolonged local anesthesia. Materials Today 2017; 20: 22-31. read more

Guo S, Kohane DS: Nanoparticulate cancer starvation therapy. Chem 2017; 168-170. read more

Kelmansky R, McAlvin JB, Nyska A, Dohlman J, Chiang HH, Hashimoto M, Kohane DS*, Mizrahi B*: Strong tissue glue with tunable elasticity. Acta Biomaterialia 2017 Apr 15;53:93-99. read more

Santamaria CM, Zhan C, McAlvin JB, Zurakowski D, Kohane DS: Tetrodotoxin, epinephrine, and chemical permeation enhancer combinations in peripheral nerve blockade. Anesth Analg 2017 Jun;124(6):1804-1812. read more

Wang Y, Kohane DS: External triggering and triggered targeting strategies for drug delivery. Nat. Rev. Mater. 2017; 2: 17020 read more

Yang R, Wei T, Goldberg H, Wang W, Cullion K, Kohane DS: Getting drugs across biological barriers. Adv Mater 2017; 29: 1606596. read more

Rwei AY, Paris JL, Wang B, Wang W, Axon CD, Vallis-Regi M, Langer R, Kohane DS: Ultrasound-triggered local anesthesia. Nat Biomed Eng 2017; 1: 644-653   read more

Rwei AY*, Wang BY*, Ji T, Zhan C, Kohane DS. Enhanced triggering of local anesthetic particles by photosensitization and photothermal effect using a common wavelength. Nano Letters 2017; 17(11):7138-7145. read more

Rwei AY*, Sherburne RT*, Zurakowski D, Wang BY, Kohane DS. Prolonged duration local anesthesia using liposomal bupivacaine combined with liposomal dexamethasone and dexmedetomidine. Anesth Analg 2018 Apr;126(4):1170-1175. PMCID: PMC5856594. read more

Prieto M*, Rwei AY*, Alejo T, Tuo W, Lopez-Franco MT, Medoza G, Sebastian V, Kohane DS*, Arruebo M*: Light emitting photon upconversion nanoparticles in the generation of transdermal reactive oxygen species. ACS Applied Materials & Interfaces 2017; 9(48):41737-41747. read more

Salvador-Culla B, Jeong KJ, Kolovou PE, Chiang HH, Chodosh J, Dohlman CH, Kohane DS: Titanium Coating of the Boston Keratoprosthesis. Trans Vis Sci Tech 2016; 5: 17. read more

Zhan C, Wang W, McAlvin JB, Guo S, Timko BP, Santamaria C, Kohane DS: Phototriggered local anesthesia. Nano Letters 2016. read more

Lim D-K*, Wylie RG*, Langer R, Kohane DS. Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF165. Biomaterials 2016. read more

Liu Q, Zhan C, Barhoumi A, Wang W, Santamaria C, McAlvin JB, Kohane DS: Supramolecular shear-thinning anti-inflammatory steroid hydrogel. Adv Mater 2016. read more 

Li L, Tong R, Li M, Kohane DS: Self-assembled gemcitabine – gadolinium nanoparticles for magnetic resonance imaging and cancer therapy. Acta Biomaterialia 2016; 33: 34-9. read more

Guo S, Nakagawa Y, Barhoumi A, Wang W, Zhan C, Tong R, Santamaria C, Kohane DS: Extended release of native drug conjugated in polyketal microparticles. J Am Chem Soc 2016. read more 

Chu H, Kohane DS, Langer R: RNA therapeutics – The potential treatment for myocardial infarction. Regen Ther 2016; 4: 83-91 (in press)

Qian Liu, Weiping Wang, Changyou Zhan, Tianshe Yang, and Daniel S. Kohane, Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance, Nano Lett., 2016, 16 (7), pp 4516–4520. read more

Li M, Li L, Zhan C,Kohane DS: Core–shell nanostars for multimodal therapy and imaging. Theranostics 2016; (in press)

Ciolino JB, Ross AE, Tulsan R, Watts AC, Wang RF, Zurakowski D, Serle JB, Kohane DS: Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys. Ophthalmology. 2016. read more

Zaman P, Wang J, Wang W, Li T, Lombardozzi NE, Kohane DS, Loscalzo J, Zhang Y: Incorporation of Proteins into Pre-formed Dextran Sulfate-Chitosan Nanoparticles. Int J Nanomed 2016; read more

Yang R, Sabharwal V, Okonkwo OS, Shlykova N, Tong R, Lin LY, Wang W, Guo S, Rosowski JJ, Pelton SI, Kohane DS: Treatment of otitis media by trans-tympanic delivery of antibiotics. Sci Transl Med 2016; (in press)

Liu Q, Zhan C, Kohane DS: Phototriggered drug delivery using inorganic nanomaterials. Bioconj. Chem. 2016; read more

Kohane DS: Drug delivery, biomaterials, and nanomedicine: an interview with Daniel Kohane. Future Sci OA 2016; read more

Bader AR, Li T, Wang W, Kohane DS, Loscalzo J, Zhang YY: Preparation and characterization of SDF-1α-chitosan-dextran sulfate nanoparticles. J Vis Exp 2015: 52323    read more

Barhoumi A, Salvador-Culla B, Kohane DS: NIR-triggered drug delivery by collagen-mediated second harmonic generation. Adv Healthc Mater 2015; 4(8):1159-63     read more

Timko BP, Kohane DS: Remote controlled drugs, Medicine Maker 2015, pp 34-7. read more

Rwei A, Wang W, Kohane DS: Photoresponsive nanoparticles for drug delivery. Nano Today 2015. read more

McAlvin JB, Zhan C, Dohlman JC, Kolovou PE, Salvador-Culla B, Kohane DS: Corneal anesthesia with site 1 sodium channel blockers and dexmedetomidine. Invest Ophthalmol Vis Sci 2015; 56(6):3820-6. read more

Tong R, Kohane DS: New strategies in cancer nanomedicine. Ann Rev Pharm Toxicol 2015; (ePub ahead of print)   read more

Barhoumi A, Liu Q, Kohane DS: Ultraviolet light-mediated drug delivery: principles, applications, and challenges. J Control Release 2015; (15)30031-6.    read more

Wang W, Liu Q, Zhan C, Barhoumi A, Wylie RG, Armstrong PA, Kohane DS: Efficient triplet-triplet annihilation-based upconversion for nanoparticle photo-targeting. Nano Letters 2015; (ePub ahead of print)     read more

Zhan C, Wang W, McAlvin JB, Guo S, Timko BP, Santamaria C, Kohane DS: Phototriggered local anesthesia. Nano Letters 2015; 16: 177-81     read more

Rwei AY, Lee JJ, Zhan C, Liu Q, Ok MT, Shankarappa SA, Langer R, Kohane DS: On-demand adjustable sciatic nerve block with phototriggerable liposomes. Proc Natl Acad Sci 2015. read more 

Ciolino JB, Stefanescu CF, Ross AE, Salvador B, Cortez P, Ford EM, Wymbs KA, Sprague SL, Mascoop DR, Rudina SS, Trauger SA, Cade F, Kohane DS: In vivo performance of a drug-eluting contact lens to treat glaucoma for a month’. Biomaterials 2014; 35: 432-9     read more

Gabriel D, Cohen-Karni T, Huang D, Chiang HH, Kohane DS: Photoactive electrospun fibers for inducing cell death. Adv Healthc Mater 2014; 3(4):494-9    read more

Timko BP, Arruebo M, Shankarappa SA, McAlvin JB, Okonkwo OS, Mizrahi B, Stefanescu CF, Gomez L, Zhu J, Zhu A, Santamaria J, Langer R, Kohane DS: Near-infrared actuated devices for remotely controlled drug delivery. Proc Natl Acad Sci USA 2014; 111(4):1349-54     read more

Hoare T, Yeo Y, Bellas E, Bruggeman JP, Kohane DS: Prevention of peritoneal adhesions using hyaluronic acid-hydroxypropylmethyl cellulose rheological blends. Acta Biomaterialia 2014; 10: 1187-93     read more

Jurek S, Hirano-Kobayashi, M, Chiang HH, Kohane DS, Matthews BD: Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red. Am J Respir Cell Mol Biol 2014; 50(6):1107-17     read more

Lee JJ, Jeong KJ, Hashimoto M, Kwon AH, Rwei A, Shankarappa SA, Tsui JH, Kohane DS: Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood. Nano Lett 2014; 14: 1-5     read more

McAlvin JB, Padera RF, Shankarappa SA, Reznor G, Kwon AH, Chiang H, Yang J, Kohane DS: Multivesicular liposomal bupivacaine at the sciatic nerve. Biomaterials 2014; 35(15):4557-64    read more

Kohane DS: Interview with Daniel Kohane. Ther Deliv 2014: 387-389

Timko BP, Kohane DS: Prospects for near-infrared technology in remotely-triggered drug delivery. Exp Opin Drug Deliv 2014; 11(11):1681-5     read more

Barhoumi A, Wang W, Zurakowski D, Langer R, Kohane D: Photothermally-targeted thermosensitive polymer-masked nanoparticles. Nano Letters 2014; 14(7):3697-701       read more

Monteiro IP, Gabriel D, Timko BP, Hashimoto M, Karajanagi S, Tong R, Marques AP, Reis RL, Kohane DS: A two-component pre-seeded dermal-epidermal scaffold. Acta Biomaterialia 2014; 10(12):4928-38     read more

Taniguchi EV, P PK, Pasquale LR, Kohane DS, Ciolino JB: Clinicians’ perspectives on the use of drug-eluting contact lenses for the treatment of glaucoma. Ther deliv 2014; 5(10):1077-83     read more

Li L, Tong R, Chu H, Wang W, Langer R, Kohane DS: Aptamer photo-regulation in vivo. Proc Natl Acad Sci 2014; 111(48):17099-103     read more

Mizrahi B, Shankarappa SA, Hickey J, Dohlman J, Timko BP, Whitehead KA, Lee JJ, Langer R, Anderson DG, Kohane DS: A stiff injectable biodegradable elastomer. Adv Func Mater 2013; 23: 1527–1533   read more

Khoo X, Simons EJ, Chiang HH, Hickey JM, Sabharwal V, Pelton SI, Rosowski JJ, Langer R, Kohane DS: Formulations for trans-tympanic antibiotic delivery. Biomaterials 2013; 34(4):1281-8   read more

Hashimoto M, Langer R, Kohane DS: Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility. Lab on a Chip 2013; 13(2):252-9   read more

Heller DA, Levi Y, Pelet JM, Pratt GW, Wallas J, Jiang S, Doloff JC, Schroeder A, Chyan Y, Sahay G, Zurenko C, Querbes W, Manzano M, Kohane DS, Langer R, Anderson DG: Modular ‘click-in-emulsion’ bone-targeted nanogels. Adv Mater 2013; 25(10):1449-54    read more

McAlvin JB, Reznor G, Shankarappa SA, Stefanescu CF, Kohane DS: Local toxicity from local anesthetic polymeric microparticles. Anesth Analg 2013; 116(4):794-803   read more

Shankarappa S, Kohane DS: Controlled release systems in neuropathic pain. Pain Management 2013; 3(2): 91-93    read more

Wang L, Shankarappa SA, Tong R, Ciolino JB, Tsui JH, Chiang HH, Kohane DS: Topical Drug Formulations for Prolonged Corneal Anesthesia. Cornea 2013; 32(7):1040-5   read more

Hashimoto M, Tong R, Kohane DS: Microdevices for nanomedicine. Mol Pharmaceutics 2013; 10(6):2127-44   read more

McAlvin JB, Kohane DS: Prolonged duration local anesthesia, Focal controlled drug delivery. Edited by Domb K. New York, Springer, 2013 (in press)

Mizrahi B, Khoo X, Chiang H, Sher K, Feldman R, Lee JJ, Irusta S, Kohane DS: Long-lasting antifouling coating with multi-armed polymer. Langmuir 2013; 29: 10087-94     read more

Lim D-K, Barhoumi A, Wylie R, Reznor G, Langer R, Kohane DS: Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide. Nano Letters 2013; 13: 4075-9     read more

Tian B, Shankarappa SA, Chiang HH, Tong R, Kohane DS: Biodegradable mesostructured polymer membranes. Nano Letters 2013; 13: 4410-5    read more

Timko BP, Kohane DS: Drug delivery systems for customized and localized drug release. Isr J Chem 2013; 53: 728-736

Gabriel D, Monteiro IP, Huang D, Langer R, Kohane DS: A photo-triggered layered surface coating producing reactive oxygen species. Biomaterials 2013; 34: 9763-9769      read more

Yin T, Bader AR, Hou TK, Maron BA, Kao DD, Qian R, Kohane DS, Handy DE, Loscalzo J, Zhang YY: SDF-1α in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules 2013; 14: 4009-20     read more

Wang LY, Tong R, Kohane DS: Synthesis and proton NMR spectroscopy of intra-vesicular gamma-aminobutyric acid (GABA). Conf Proc IEEE Eng Med Biol Soc 2013; 2013: 1093-1095     read more

Tong R, Chiang HH, Kohane DS: Photoswitchable nanoparticles for in vivo cancer chemotherapy. Proc Natl Acad Sci USA 2013; 110: 19048-53     read more

Tian B, Liu J, Dvir T, Jin L, Tsui JH, Qing Q, Suo Z, Langer R, Kohane DS*, Lieber CM*: Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat Mater 2012; 11: 986-94  read more

Cohen-Karni T, Jeong KJ, Tsui J, Reznor G, Mustata M, Wanunu M, Graham A, Marks C, Bell D, Langer R, Kohane DS: Nanocomposite gold-silk nanofibers. Nano Letters 2012; 12(10): 5403–5406  read more

Cohen-Karni T, Langer R, Kohane DS: The smartest materials: the future of nanoelectronics in medicine. ACS Nano 2012; 6(8): 6541–6545  read more

Hoare T, Sivakumaran D, Stefanescu CF, Lawlor MW, Kohane DS: Nanogel scavengers for drugs. Acta Biomaterialia 2012; 8: 1450-8  read more

Shichor I, Shomron N, Lawlor MW, Bae SA, Zoldan J, Langer R, Kohane DS: Toxicogenomic analysis of a sustained release local anesthetic delivery system. Biomaterials 2012; 33: 3586-93  read more

Epstein-Barash H, Stefanescu CF, Kohane DS: An in situ cross-linking hybrid hydrogel for controlled release of proteins. Acta Biomater 2012; 8: 1703-9  read more

Tong R, Hemmatti HD, Langer R, Kohane DS: Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. J Amer Chemical Soc 2012; 134: 8848-55  read more

Shankarappa SA, Sagie I, Tsui JH, Chiang HH, Stefanescu CF, Zurakowski D, Kohane DS: Duration and local toxicity of sciatic nerve blockade with co-injected site 1 sodium channel blockers and quaternary lidocaine derivatives. Reg Anesth Pain Med 2012; 37: 483-9  read more

Gabriel D, Dvir T, Kohane DS: Delivering bioactive molecules as instructive cues to engineered tissues. Expert Opin Drug Deliv 2012; 9(4):473-92   read more

Timko B, Kohane DS: Research Highlights: Novel resonating nanowire arrays function as highly sensitive biosensors. Nanomedicine (Lond.) 2012; 7:315-6   read more

Tong R, Kohane DS: Shedding light on nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2012; 4(6), 638–662  read more

Hoare T, Young S, Lawlor MW, Kohane DS: Thermoresponsive nanogels for prolonged duration local anesthesia. Acta Biomater 2012; 8: 3596-605  read more

Shankarappa, S. A.; Tsui, J. H.; Kim, K. N.; Reznor, G.; Dohlman, J. C.; Langer, R.; Kohane, DS:  Prolonged Nerve Blockade Delays the Onset of Neuropathic Pain. Proceedings of the National Academy of Sciences 2012; 109: 17555–17560 read more

Weldon CB, Tsui JH, Shankarappa SA, Nguyen VT, Ma M, Anderson DG, Kohane DS: Electrospun drug-eluting sutures for local anesthesia. J Control Release 2012; 1661: 903-9   read more

Ciolino JB, Hudson SP, Mobbs AN, Hoare TR, Iwata N, Fink GR, Kohane DS: A prototype antifungal contact lens. Invest Ophthalmol Vis Sci 2011; 52: 6286-91  read more

Mizrahi B, Stefanescu CF, Yang C, Lawlor MW, Ko D, Langer R, Kohane DS: Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. Acta Biomaterialia 2011; 7: 3150-7  read more

Jeong KJ, Wang L, Stefanescu CF, Lawlor MW, Polat J, Dohlman CH, Langer R, Kohane DS: Polydopamine coatings enhance biointegration of a model polymeric implant. Soft Matter 2011; 7: 8305-12   read more

Malavia N, Zurakowski D, Schroeder A, Princiotto A, Laury A, Epstein-Barash H, Sodroski J, Langer R, Madani N, Kohane DS: Liposomes for HIV prophylaxis. Biomaterials 2011; 32: 8663-8    read more

Wang L, Jeong KJ, Chiang HH, Zurakowski D, Behlau I, Chodosh J, Dohlman CH, Langer R, Kohane DS: Hydroxyapatite for keratoprosthesis biointegration. Invest Ophthalmol Vis Sci 2011; 52: 7392-9   read more

Dvir T, Timko B, Brigham MD, Naik SR, Karajanagi SS, Levy O, Jin H, Parker KK, Langer R, Kohane DS: Nanowired three dimensional cardiac patches. Nat Nanotechnol 2011; 6: 720-5   read more

Dvir T, Bauer M, Schroeder A, Tsui J, Anderson DG, Langer R, Liao R, Kohane DS: Nanoparticles targeting the infarcted heart. Nano Letters 2011; 11: 4411-4   read more

Dvir T, Timko BP, Kohane DS, Langer R: Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol 2011; 6: 13-22  read more

Mizrahi B, Weldon C, Kohane DS: Tissue adhesives as active implants, Active Implants and Scaffolds for Tissue Regeneration. Edited by Zilberman M, Springer, 2011     read more

Weldon C, Tian B, Kohane DS: Nanotechnology for surgeons. Nanotechnol Nanobiotechnol 2011; 3: 223-8  read more

Timko BP, Whitehead K, Gao W, Kohane DS, Farokhzad O, Anderson D, Langer R: Advances in drug delivery. Annu Rev Mater Res 2011; 41: 1-20  read more

Jeong KJ, Kohane DS: Surface modification and drug delivery for biointegration. Ther Deliv 2011; 2: 737-52   read more

Mizrahi B, Irusta S, McKenna M, Stefanescu C, Yedidsion L, Myint M, Langer R, Kohane DS: Microgels for efficient protein purification. Adv Mater 2011; 23: H2258-62     read more

Hoare T, Timko BP, Santamaria J, Goya GF, Irusta S, Lau S, Stefanescu CF, Lin D, Langer R, Kohane DS: Magnetically-triggered nanocomposite membranes: a versatile platform for triggered drug release. Nano Letters 2011; 11: 1395-400   read  more

Hudson SP, Langer R, Fink GR, Kohane DS: Injectable in situ cross-linking hydrogels for local antifungal therapy. Biomaterials 2010; 31: 1444-52   read more

Dvir T, Banghart MR, Timko BP, Langer R, Kohane DS: Photo-targeted nanoparticles. Nano Letters 2010; 10: 250-4   read more

Hoare T, Zurakowski D, Langer R, Kohane DS: Rheological blends for drug delivery. I: Characterization in vitro. J Biomed Mater Res A 2010; 92: 575-85   read more

Hoare T, Bellas E, Zurakowski D, Kohane DS: Rheological blends for drug delivery. II: Prolongation of nerve blockade, biocompatibility, and in vitro-in vivo correlations. J Biomed Mater Res A 2010; 92: 586-95   read more

Sagie I, Kohane DS: Prolonged sensory-selective nerve blockade. Proc Natl Acad Sci USA 2010; 106: 7125-30  read more

Epstein-Barash H, Orbey G, Polat BE, Ewoldt RE, Feshitan J, Langer R, Borden MA, Kohane DS: A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. Biomaterials 2010; 31: 5208-17   read more

Yang F, Cho SW, Son SM, Hudson SP, Bogatyrev S, Keung L, Kohane DS, Langer R, Anderson DG: Combinatorial Extracellular Matrices for Human Embryonic Stem Cell Differentiation in 3D. Biomacromolecules 2010; 11:1909-14   read more

Kohane DS, Langer R: Biocompatibility and drug delivery systems. Chemical Science 2010; 1: 441-446  read more

Timko B, Dvir T, Kohane DS: Remotely triggerable drug delivery systems. Adv Mater 2010; 22: 4925-4943  read more

Kohane DS, Langer R: Drug delivery and translation. Drug Deliv Trans Res 2010; 1:1

George PM, Saigal R, Lawlor MW, Moore MJ, LaVan DA, Marini RP, Selig M, Makhni M, Burdick JA, Langer R, Kohane DS: Three-dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A 2009; 91: 519-27   read more

Xu P, Gullotti E, Tong L, Highley CB, Errabelli DR, Hasan T, Cheng J-X, Kohane DS, Yeo Y: Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Mol Pharmaceutics 2009; 6: 190-201  read more

Ciolino JB, Hoare TR, Iwata NG, Behlau I, Dohlman CH, Langer R, Kohane DS: A drug-eluting contact lens. Invest Ophthalmol Vis Sci 2009; 50: 3346-42   read more

Simons EJ, Bellas E, Lawlor MW, Kohane DS: Effect of chemical permeation enhancers on nerve blockade. Mol Pharmaceutics 2009; 6: 265-273  read more

Xu Q, Hashimoto M, Dang TT, Hoare T, Kohane DS, Whitesides GM, Langer R, Anderson DG: Preparation of monodisperse drug-loaded polymer microparticles using a microfluidic flow-focusing device. Small 2009; 5: 1575-81   read more

Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS: Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci USA 2009; 106: 7125-30    read more

Hoare T, Santamaria J, Goya GF, Irusta S, Lin D, Lau S, Padera R, Langer R, Kohane DS: A magnetically triggered composite membrane for on-demand drug delivery. Nano Letters 2009; 9: 3651-7   read more

Ciolino JB, Dohlman CH, Kohane DS: Contact lenses for drug delivery. Seminars in ophthalmology 2009; 24: 156-60    read more

Ciolino JB, Kohane DS: General considerations in designing a drug-eluting contact lens. Expert Rev Ophthalmol 2009; 4: 569-571  read more

Bruggeman JP, Bettinger CJ, Nijst CLE, Kohane DS, Langer R: Biodegradable xylitol-based polymers. Adv Mater 2008; 20: 1922-1927  read more

Ferreira L, Squier T, Park H, Choe H, Kohane DS, Langer R: Human embryoid bodies containing nano- and microparticulate delivery vehicles. Adv Mater 2008; 20: 2285-2291  read more

Padera R, Bellas E, Tse JY, Hao DD, Kohane DS: Local myotoxicity from sustained release of bupivacaine from microparticles. Anesthesiology 2008; 108: 921-8   read more

Hudson SP, Padera RF, Langer R, Kohane DS: The biocompatibility of mesoporous silicates. Biomaterials 2008; 29: 4045-4055  read more

Domnina YA, Yeo Y, Tse JY, Bellas E, Kohane DS: Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum. J Biomed Mater Res A 2008; 87: 825-31   read more

Tsifansky MD, Yeo Y, Evgenov OV, Bellas E, Benjamin J, Kohane DS: Microparticles for inhalational delivery of antipseudomonal antibiotics. AAPS Journal 2008; 10: 254-60    read more

Yeo Y, Kohane DS: Polymers in the prevention of peritoneal adhesions. Eur J Pharm Biopharm 2008; 68: 57-66   read more

Little SR, Kohane DS: Polymers for intracellular delivery of nucleic acids. J Mater Chem 2008; 18: 832-841    read more

Kohane DS, Langer R: Polymeric biomaterials in tissue engineering. Pediatr Res 2008; 63:487-91  read more

Hoare T, Kohane DS: Hydrogels in drug delivery: progress and challenges. Polymer 2008; 49: 1993-2007   read more

Kohane DS: Micro- and nanoparticles for drug delivery, World of Food Science, 2008  read more

Yeo Y, Kohane DS: A hybrid system for preventing postsurgical adhesions. Ann Surg 2008; 247: 712  read more

Yeo Y, Ito T, Bellas E, Highley CB, Marini R, Kohane DS: In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing post-surgical adhesions. Ann Surg 2007; 245: 819-824   read more

Zumbuehl A, Ferreira L, Kuhn D, Asthashkina A, Long L, Yeo Y, Iaconis T, Ghannoum M, Fink GR*, Langer R*, Kohane DS*: Antifungal hydrogels. Proc Natl Acad Sci USA 2007; 104: 12994-8   read more

Ito T, Yeo Y, Highley CB, Bellas E, Benitez CA, Kohane DS: The prevention of peritoneal adhesions by in-situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives. Biomaterials 2007; 28: 975-8335   read more

Ito T, Fraser IP, Yeo Y, Highley CB, Bellas E, Kohane DS: Anti-inflammatory function of an in-situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone. Biomaterials 2007; 28: 1778-1786   read more

Ito T, Yeo Y, Highley CB, Bellas E, Kohane DS: Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions. Biomaterials 2007; 28: 3414-3426   read more

Yeo Y, Bellas E, Highley CB, Langer R, Kohane DS: Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model. Biomaterials 2007; 28: 3704-13   read more

Yeo Y, Adil M, Bellas E, Astashkhina A, Chaudary N, Kohane DS: Prevention of peritoneal adhesions with an in situ cross-linkable hyaluronan hydrogel delivering budesonide. J Control Release 2007; 120: 178-85   read more

Evgenov OV*, Kohane DS*, Bloch KD, Stasch JP, Volpato GP, Bellas E, Evgenov NV, Buys ES, Gnoth MJ, Graveline AR, Liu R, Hess DR, Langer R, Zapol WM: Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med 2007; 176: 1138-45    read more

Kohane DS: Microparticles and nanoparticles for drug delivery. Biotechnol Bioeng 2007; 96: 203-209    read more

Kohane DS, Tse JY, Yeo Y, Padera R, Shubina M, Langer R: Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. J. Biomed. Mat. Res. 2006; 77: 351-361   read more

Karp JM, Yeo Y, Geng W, Cannizarro C, Yan K, Kohane DS, Vunjak-Novakovic G, Langer R, Radisic M: A photolitographic method to create cellular micropatterns. Biomaterials 2006; 27: 4755-64   read more

Yeo Y, Highley CB, Bellas E, Ito T, Marini R, Langer R, Kohane DS: In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model. Biomaterials 2006; 27: 4698-4705   read more

Fukuda J, Khademhosseini A, Yeo Y, Yang X, Yeh J, Eng G, Blumlimg J, Wang C-F, Kohane DS, Langer R: Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures. Biomaterials 2006; 27: 5259-67   read more

Yeo Y, Burdick JA, Highley CB, Marini R, Langer R, Kohane DS: Peritoneal application of chitosan and UV-cross-linkable chitosan. J Biomed Mater Res 2006; 78: 668-75   read more

Padera R, Tse J, Bellas E, Kohane DS: Tetrodotoxin for prolonged local anesthesia with minimal myotoxicity. Muscle Nerve 2006; 34: 747-753   read more

Yeo Y, Geng W, Burdick J, Ito T, Kohane DS, Burdick JA, Radisic M: A photocrosslinkable hydrogel for myocyte cell culture and injection. J Biomed Mater Res B 2006; 81B: 312-322   read more

Jia X, Yeo Y, Clifton RJ, Jiao T, Kohane DS, Kobler J, Zeitels SM, Langer R: Hyaluronic Acid-Based Microgel System for Vocal Fold Regeneration. Biomacromolecules 2006; 7: 3336-3344    read more

Kohane DS. Massachusetts General Hospital for Children Pediatric Medications Administration Process Manual for Syringe Pumps, Nathaniel Sims Senior Ed., 1st Edition, 2006

LaVan DA, Padera RF, Friedmann TA, Sullivan JP, Langer R, Kohane DS: In Vivo evaluation of tetrahedral amorphous carbon. Biomaterials 2005; 26: 465-473  read more

Levenberg S, Rouwkema J, Macdonald M, Garfein E, Kohane DS, Darland D, Marini R, Mulligan R, D’Amore P, Langer R: Engineering vascularized skeletal muscle tissue. Nat Biotechnol 2005; 23: 879-884   read more

Colombo G, Padera R, Langer R, Kohane DS: Prolonged duration local anesthesia with lipid-protein-sugar particles containing bupivacaine and dexamethasone. J Biomed Mater Res 2005; 75A: 458-464  read more

Yeo Y, Bellas E, Firestone W, Langer R, Kohane DS: Complex coacervates for thermally sensitive controlled release of flavor compounds. J Agric Food Chem 2005; 53: 7518-25   read more

Barnet C, Louis DN, Kohane DS: Tissue injury from tricyclic antidepressants used as local anesthetics. Anesth Analg 2005; 101:1838-1843    read more

Kohane DS, Ingelfinger J. Case records of the Massachusetts General Hospital. Case 16-2005. A nine-year-old girl with headaches and hypertension. N Engl J Med 2005; 352: 2223-31.   read more

Kohane DS, Langer R. Biotechnology for Drug Delivery to Improve Patient Compliance. Behavioral Health Management 2005; 25: 26-28

Haining WN, Anderson DG, Little SR, von Berwelt-Baildon MS, Cardoso AA, Alves P, Kosmatopoulos K, Nadler LM, Langer R, Kohane DS: pH-triggered microparticles for peptide vaccination. J. Immunol. 2004; 174: 2578-2585  read more

Colombo G, Langer R, Kohane DS: Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. J. Biomed. Mater. Res. 2004; 68A: 651-659    read more

Thomas TT, Kohane DS, Wang A, Langer R: Microparticulate formulations for controlled release of IL-2. J Pharm Sci 2004; 93: 1100-1109  read more

Jia X, Colombo G, Padera R, Langer R, Kohane DS: Prolongation of sciatic nerve blockade by in situ crosslinked hyaluronic acid. Biomaterials 2004; 25: 4797-4804  read more

Barnet C, Tse J, Kohane DS: Site 1 sodium channel blockers prolong the duration of sciatic nerve blockade from tricyclic antidepressants. Pain 2004; 110: 432-438   read more

Chen PC, Park YJ, Chang LC, Kohane DS, Barlett RH, Langer R, Yang VC: Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization. J Biomed Mater Res 2004; 70A: 412-419    read more

Chen PC, Kohane DS, Park YJ, Barlett RH, Langer R, Yang VC: Injectable microparticle-gel system for prolonged and localized lidocaine release. II. In vivo anesthetic effects. J Biomed Mater Res 2004; 70A: 459-466  read more

Kohane DS, Smith SE, Louis DN, Colombo G, Ghoroghchian P, Hunfeld NGM, Berde CB, Langer RS: Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain 2003; 104: 415-421    read more

Fauza DO, Kohane DS, Beewukes E, Clayton N, Maher TS: Local anesthetics inhibit myometrial activity in vitro: possible application on preterm labor prevention and treatment. Fetal Diagn Ther 2003; 18: 292-296  read more

Kohane DS, Anderson DG, Yu C, Langer R: pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharm Res 2003; 20: 1533-1542  read more

Kohane DS, Plesnila N, Thomas SS, Le D, Langer R, Moskowitz MA: Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. Brain Res 2002; 946: 206-13  read more

Kohane DS, Lipp M, Kinney RC, Anthony DC, Louis DN, Lotan N, Langer R: Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res 2002; 59: 450-9 read more

Kohane DS, Cheng L-A, Noviski N: Disorders of temperature regulation, Gellis & Kagan’s Current Pediatric Therapy, 17th Edition. Edited by Burg. Philadelphia, Harcourt, 2002. read more

Kohane DS, Lu NT, Crosa GA, Kuang Y, Berde CB: High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin. Acta Anaesthesiol Scand 2001; 45: 899-905 read more

Kohane DS, Lu NT, Cairns BE, Berde CB: Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block. Reg Anesth Pain Med 2001; 26: 239-45   read more

Plesnila N, Zinkel S, Le DA, Amin-Hanjani S, Wu Y, Qiu J, Chiarugi A, Thomas SS, Kohane DS, Korsmeyer SJ, Moskowitz MA: BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia. Proc Natl Acad Sci USA 2001; 98: 15318-23 read more

Kohane DS, Lipp M, Kinney RC, Lotan N, Langer R: Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine. Pharm Res 2000; 17: 1243-9 read more

Kohane DS, Lu NT, Gokgol-Kline AC, Shubina M, Kuang Y, Hall S, Strichartz GR, Berde CB: The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Reg Anesth Pain Med 2000; 25: 52-9 read more

Kohane DS, Kuang Y, Lu NT, Langer R, Strichartz GR, Berde CB: Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology 1999; 90: 524-34 read more

Kohane DS, Ringer, S. The Way of the NICU, 1999. This is a pocket manual of neonatology commissioned and published by the Joint Program of Neonatology at Harvard, that was issued (in various editions) to all residents coming through that program for more than a decade.

Kohane DS, Yieh J, Lu NT, Langer R, Strichartz GR, Berde CB: A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology 1998; 89: 119-31 read more

Kohane DS, Sankar WN, Shubina M, Hu D, Rifai N, Berde CB: Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. Anesthesiology 1998; 89: 1199-208 read more

Ficchione G, Kohane DS, Daly R, Todres ID: Psychopharmacology in the intensive care unit. New Horizons 1998; 6: 353-362

Kohane DS, Tobin T, Kohane I: Endocrine, mineral and metabolic disease, Handbook of pediatric intensive care. Edited by Rogers MC, Helfaer MA. Baltimore, Williams & Wilkins, 1998, pp. 684-730

Kohane DS, Tobin T, Kohane I: Endocrine, mineral and metabolic disease in pediatric intensive care, Textbook of pediatric intensive care. Edited by Rogers MC, Nichols DG. Baltimore, Williams & Wilkins, 1996, pp 1247-1314

Kohane DS, Sarzani R, Schwartz JH, Chobanian AV, Brecher P: Stress-induced proteins in aortic smooth muscle cells and aorta of hypertensive rats. Am J Physiol 1990; 258: H1699-705