The ability to trigger drug release from a device (i.e. on-demand drug delivery) can enable control over the exact timing (onset and offset) and magnitude of therapeutic effect, and also provide spatiotemporal control which can enhance the therapeutic index. We have developed nano-, micro-, and macroscopic triggerable drug delivery systems that respond to external energy sources including light, ultrasound, and magnetism. Read More …
We are interested in methods for getting drugs into the middle ear by non-invasive means using a range of drug delivery technologies. Read More …
We are looking at light as a trigger and targeting for drug delivery systems, as well as for surface reactions. Read More …
The ability to deliver drugs and drug-containing particles specifically to target tissues has the potential to enhance therapeutic effect and reduce systemic toxicity. We have developed particles that are directed to their targets by light, ligands, or both. Read More …
We have an active interest in the use of inorganic nanomaterials for a range of applications including triggerable nanomaterials and surfaces, bio-applications of nanoelectronics, and tissue-engineered nanocomposites. Read More …
We are studying a range of topics including nanoparticulate drug delivery systems, nanostructured engineered tissues, and nanoscale sensors. These are further applied in triggered and/or targeted systems, as well as tissue engineering applications. Our interests extend to the use of inorganic nanomaterials. Read More …
This is the longest-running area of research in our laboratory. We have designed and developed a range of formulations to produce prolonged nerve blockade, including drugs in free solution, or associated with chemical permeation enhancers, micro-and nanoparticles, hydrogels, and others drug delivery systems. We have a particular interest in means of preventing or at least mitigating the development of neuropathic pain. Read More …
On December 18th, the Kohane group got together to celebrate the holidays with the annual Swiss tradition called L’Escalade, or Fête de l’Escalade. The annual Escalade festival is held in December in Geneva, Switzerland, celebrating the defeat of the surprise attack by troops sent by Charles Emmanuel I, Duke of Savoy during the night of Read More …
On Saturday, November 3rd, Joe Ciolino and his family welcomed their second child into the family. Benjamin Ciolino was born at 2:30am and is pictured here with mother and brother.
On October 25th, Dr. Bozhi Tian was recognized by MIT’s Technology Review as a TR35 Honoree for 2012. The TR35 award recognizes the world’s top innovators in emerging fields of science and technology under the age of 35. Bozhi has been recognized for his inventions on field effect transistor based intracellular probes and nanoelectronics ‘innervated’ synthetic Read More …