Laboratory of Daniel S. Kohane
  • Ocular Drug Delivery

    Ocular Drug Delivery

    Published January 10, 2013 - No Comments

    We have an ongoing project to develop contact lenses that elute drugs for days to weeks, improving drug delivery and mitigating the problems associated with patient compliance. Other projects relate to drug delivery to the back of the eye using nanoparticles, hydrogels, and drug conjugates.

    read more
  • Triggered Drug Delivery Systems

    Triggered Drug Delivery Systems

    Published January 9, 2013 - No Comments

    The ability to trigger drug release from a device (i.e. on-demand drug delivery) can enable control over the exact timing (onset and offset) and magnitude of therapeutic effect, and also provide spatiotemporal control which can enhance the therapeutic index. We have developed nano-, micro-, and macroscopic triggerable drug delivery systems that respond to external energy sources including light, ultrasound, and magnetism.

    read more
  • Trans-Tympanic Drug Delivery

    Trans-Tympanic Drug Delivery

    Published January 9, 2013 - No Comments

    We are interested in methods for getting drugs into the middle ear by non-invasive means using a range of drug delivery technologies.

    read more
  • Light-Responsive Systems

    Light-Responsive Systems

    Published January 9, 2013 - No Comments

    We are looking at light as a trigger and targeting for drug delivery systems, as well as for surface reactions.

    read more
  • Targeted Drug Delivery Systems

    Targeted Drug Delivery Systems

    Published January 9, 2013 - No Comments

    The ability to deliver drugs and drug-containing particles specifically to target tissues has the potential to enhance therapeutic effect and reduce systemic toxicity. We have developed particles that are directed to their targets by light, ligands, or both.

    read more
  • Inorganic Nanomaterials

    Inorganic Nanomaterials

    Published December 19, 2012 - No Comments

    We have an active interest in the use of inorganic nanomaterials for a range of applications including triggerable nanomaterials and surfaces, bio-applications of nanoelectronics, and tissue-engineered nanocomposites.

    read more
  • Nanomedicine

    Nanomedicine

    Published December 19, 2012 - No Comments

    We are studying a range of topics including nanoparticulate drug delivery systems, nanostructured engineered tissues, and nanoscale sensors. These are further applied in triggered and/or targeted systems, as well as tissue engineering applications. Our interests extend to the use of inorganic nanomaterials.

    read more
  • Prolonged Duration Local Anesthesia

    Prolonged Duration Local Anesthesia

    Published December 19, 2012 - No Comments

    This is the longest-running area of research in our laboratory. We have designed and developed a range of formulations to produce prolonged nerve blockade, including drugs in free solution, or associated with chemical permeation enhancers, micro-and nanoparticles, hydrogels, and others drug delivery systems. We have a particular interest in means of preventing or at least mitigating the development of neuropathic pain.

    read more
  • Ocular Drug Delivery
  • Triggered Drug Delivery Systems
  • Trans-Tympanic Drug Delivery
  • Light-Responsive Systems
  • Targeted Drug Delivery Systems
  • Inorganic Nanomaterials
  • Nanomedicine
  • Prolonged Duration Local Anesthesia

Our laboratory addresses a wide range of topics in drug delivery, developing whatever approach seems most apposite. This has included polymeric and other microparticles and nanoparticles, liposomes, hydrogels, targeted particles, macroscopic devices, and combinations of the above. We have a very active research program in nanomedicine.


Some particular areas of interest include:
  • Prolonged Duration Local Anesthesia
  • Nanomedicine
  • Targeted Drug Delivery Systems
  • Triggered Drug Delivery Systems
  • Light-Responsive Systems
  • Trans-Tympanic Drug Delivery
  • Inorganic Nanomaterials
  • Ocular Drug Delivery