Star Alert!
Dan was recently recognized for kindness and going above and beyond during his clinical service. He stayed beyond his shift to ensure that a nervous patient was comfortable throughout a procedure. Way to go Dan!
Author: kohanelab
Sensory Selective Sciatic Nerve Block with 2’,6’ Pipecolylxylidine in an Ovine Model.
Cullion K*, Clarke A, Han Y, Xue T, Weldon E, Li Y, Nedder A, Kohane DS*: Sensory Selective Sciatic Nerve Block with 2’,6’ Pipecolylxylidine in an Ovine Model. Anesthesiology 2026; (in press)
Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2′,6′-Pipecoloxylidide.
Chen S, Wang Y, CHeng M, Chang J, Sha Y, Du D, Chen J*, Guo W*, Kohane DS*, Zheng Y*: Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2′,6′-Pipecoloxylidide. Angew Chem Int Ed 2026; (in press)
Polymeric Rapamycin Nanoparticles Encapsulating Ponatinib Cause Regression of Venous Malformations in Mice.
Tang W, Li Y, Boscolo E, Kohane DS*, Cullion K*: Polymeric Rapamycin Nanoparticles Encapsulating Ponatinib Cause Regression of Venous Malformations in Mice. Sci Transl Med 2026; 18(848):eaeb7597; read more
Polyketal-conjugated tafluprost microparticles enable long-acting glaucoma therapy.
Zhong H, Wei T, Zhou X, Yu N, Nakagawa Y, Samtamaria C, Gordon A, Wang W, Mu J, Zhan C, Barhoumi A, Yuan X, Kohane DS*, Guo S*: Polyketal-conjugated tafluprost microparticles enable long-acting glaucoma therapy. Nat Commun 2026; (in press)
Zhenrui Fan
Education: Zhenrui is currently pursuing his B.S. degree in Chemistry from Nankai University (expected 2027). Research interests: Zhenrui’s research focuses on the development of advanced drug delivery systems and nanomedicine by integrating innovative materials, including novel inorganic matrices, synthetic polymers, and plastics. His work aims to engineer multifunctional platforms for the controlled and targeted release Read More …
Kavitha Muralidharan, MD, MTR
Education: Kavitha majored in neuroscience at the University of Pennsylvania. She attended medical school at the University of Pennsylvania, Perelman School of Medicine, and completed her masters in translational research there as well. She went on to complete her pediatrics residency at New York Presbyterian Columbia (CHONY) and is currently a critical care fellow at Read More …
Besifloxacin-eluting contact lens with sustained drug delivery and enhanced bioavailability.
Kuang L, Boychev N, Chen L, Ross AE, Kanu LN, Miura M, Peng C, Yung A, Yeung V, Romanowski EG, Dana R, Kohane DS, Ciolino JB: Besifloxacin-eluting contact lens with sustained drug delivery and enhanced bioavailability. Int J Pharm X 2026; 11:100511; read more
Extended local anesthesia enabled by flavonoid permeation enhancers.
Han Y, Torre M, Ma X, Xue T, Wang Y, Jo S, Fujita A, Bean BP, Kohane DS: Extended local anesthesia enabled by flavonoid permeation enhancers. Proc Natl Acad Sci 2026; e2523195123; read more
Kohane Lab Chinese New Year Celebration
The Kohane Lab celebrated the Year of the Horse with lunch at LaMei Hot Pot in Brookline!