Author: kohanelab
We Are Moving!
We are excited to announce that the Kohane Lab has recently moved to a brand new lab! We are now located at the Harvard Institutes of Medicine Building on the 9th Floor. This past year has been full of great work and growth, and we look forward to continued success in our beautiful new space Read More …
Annual Escalade Party 2019
The Kohane Lab annual Escalade Party was a great success! Each year, this party celebrates Dan’s hometown of Geneva and its successful defense against an attempted conquest. Troops from the Duchy of Savoy attempted a surprise invasion on the city in the December of 1602, but (according to legend) were repulsed by a cook who dumped Read More …
The duration of nerve block from local anesthetic formulations in male and female rats
Cullion K*, Petishnok LC*, Ji T, Zurakowski D, Kohane DS: The duration of nerve block from local anesthetic formulations in male and female rats. Pharm Res 2019; 36:179. read more
Nanoscale systems for local drug delivery
Ji T, Kohane DS: Nanoscale systems for local drug delivery. Nano Today 2019; 28: 100765. read more
Prolonged duration topical rorneal anesthesia with the cationic lidocaine derivative QX-314
Woodruff A, Santamaria CM, Mehta M, Pemberton GL, Cullion K, Kohane DS: Prolonged duration topical rorneal anesthesia with the cationic lidocaine derivative QX-314. Trans Vis Sci Tech 2019; 8:28. read more
A simple yet multifunctional nanoformulation for eradicating tumors and preventing recurrence with safely low administration dose
Liu Y, Xu Y, Zhang Z, Huo Y, Chen D, Ma W, Sun K, Tonga G, Zhou G, Kohane DS, Tao K: A simple yet multifunctional nanoformulation for eradicating tumors and preventing recurrence with safely low administration dose. Nano Letters 2019; 19: 5515-5523. read more
Topical sustained drug delivery to the retina with a drug-eluting contact lens.
Ross AE*, Bengani LC*, Tulsan R, Maidana DE, Salvador-Culla B, Kobashi H, Kolovou PE, Zhai H, Taghizadeh K, Kuang L, Mehta M, Vavvas D, Kohane DS*, Ciolino JB*: Topical sustained drug delivery to the retina with a drug-eluting contact lens. Biomaterials 2019; read more
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK: Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proc Natl Acad Sci USA 2019; read more
Polymer-tetrodotoxin conjugates to induce adjustable and prolonged duration local anesthesia with minimal toxicity
Zhao C*, Liu A*, Santamaria CM, Shomorony A, Ji T, Wei T, Gordon A, Elofsson H, Mehta M, Yang R, Kohane DS: Polymer-tetrodotoxin conjugates to induce adjustable and prolonged duration local anesthesia with minimal toxicity. Nat Commun 2019; 10: 2566. read more